Abteilung für Transfusionsmedizin der Universität Rostock
Kiefel V, König C, Kroll H, Santoso S: Platelet alloantibodies in transfused patients. Transfusion 2001;41:766-770.
Sachs UJ, Kiefel V, Böhringer M, Afshar-Kharghan V, Kroll H, Santoso S: Single amino acid substitution in human platelet glycoprotein Ib(beta) is responsible for the formation of the platelet-specific alloantigen Iy(a). Blood 2000;95:1849-1855.
Santoso S, Amrhein J, Hofmann HA, Sachs UJ, Walka MM, Kroll H, Kiefel V: A point mutation Thr(799)Met on the alpha(2) integrin leads to the formation of new human platelet alloantigen Sit(a) and affects collagen-induced aggregation. Blood 1999;94:4103-4111.
Carlsson LE, Santoso S, Baurichter G, Kroll H, Papenberg S, Eichler P, Westerdaal NAC, Kiefel V, van de Winkel JGJ, Greinacher A: Heparin-induced thrombocytopenia: New insights into the impact of the Fc(gamma)RIIa-R-H131 polymorphism. Blood 1998;92:1526-1531.
Brunner-Bollinger S, Kiefel V, Horber FF, Nydegger UE, Berchtold P: Antibody studies in a patient with acute thrombocytopenia following infusion of plasma containing anti-Pl(A1). Am J Hematol 1997;56:119-121.
Mizon P, Kiefel V, Mannessier L, Mueller-Eckhardt C, Goudemand J: Thrombocytopenia induced by vancomycin-dependent platelet antibody. Vox Sang 1997;73:49-51.
Giers G, Hoch J, Bauer H, Bald R, Kiefel V, Kroll H, Hansmann M, Hanfland P, Mueller-Eckhardt C, Scharf RE: Therapy with intravenous immunoglobulin G (ivIgG) during pregnancy for fetal alloimmune (HPA-1a(Zw(a))) thrombocytopenic purpura. Prenat Diagn 1996;16:495-502.
Berchtold P, Müller D, Beardsley D, Fujisawa K, Kaplan C, Kekomäki R, Lipp E, Morel-Kopp MC, Kiefel V, McMillan R, von dem Borne AEGK, Imbach P: International study to compare antigen-specific methods used for the measurement of antiplatelet autoantibodies. Br J Haematol 1997;96:477-483.
Santoso S, Vicariot M, Böhringer M, Sachs U, Kroll H, Mueller-Eckhardt C, Kiefel V: The platelet-specific alloantigen Iy(a) is associated with point mutation of glycoprotein Ib(beta). Submitted for publication nnnn;nn:nn.
Kiefel V, Freitag E, Kroll H, Santoso S, Mueller-Eckhardt C: Platelet autoantibodies (IgG, IgM, IgA) against glycoproteins IIb/IIIa and Ib/IX in patients with thrombocytopenia. Ann Hematol 1996;72:280-285.
Koksch M, Rothe G, Kiefel V, Schmitz G: Fluorescence resonance energy transfer as a new method for the epitope-specific characterization of anti-platelet antibodies. J Immunol Methods 1995;187:53-67.
Wiemer M, Kreuzpaintner G, Lauer B, Kiefel V, Schultheiss HP, Horstkotte D, Strauer B: Rezidivierende Immunthrombozytopenie. Seltene Komplikation nach Kontrastmittelexposition. Dtsch Med Wochenschr 1995;120:1236-1240.
Kiefel V, Vicariot M, Giovangrandi Y, Kroll H, Böhringer M, Greinacher A, Breitfeld C, Santoso S, Mueller-Eckhardt C: Alloimmunization against Iy, a low-frequency antigen on platelet glycoprotein Ib/IX as a cause for severe neonatal alloimmune thrombocytopenic purpura. Vox Sang 1995;69:250-254.
Unkelbach K, Kalb R, Santoso S, Kroll H, Mueller-Eckhardt C, Kiefel V: Genomic RFLP typing of human platelet alloantigens Zw (Pl(A)), Ko, Bak and Br (HPA-1, 2, 3, 5). Br J Haematol 1995;89:169-176.
Greinacher A, Amiral J, Dummel V, Vissac A, Kiefel V, Mueller-Eckhardt C: Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin induced platelet activation (HIPA) test, and platelet factor 4/heparin enzyme-linked immunosorbent assay. Transfusion 1994;34:381-385.
Santoso S, Kalb R, Kroll H, Walka M, Kiefel V, Mueller-Eckhardt C, Newman PJ: A point mutation leads to an unpaired cysteine residue and a molecular weight polymorphism of a functional platelet beta(3) integrin subunit. The Sr(a) alloantigen system of GPIIIa. J Biol Chem 1994;269:8439-8444.
Kroll H, Kiefel V, Mueller-Eckhardt C: Posttransfusionelle Purpura: Klinische und immunologische Untersuchungen bei 38 Patientinnen. Infusionsther Transfusionsmed 1993;20:198-204.
Unkelbach K, Kalb R, Breitfeld C, Santoso S, Kiefel V, Mueller-Eckhardt C: New polymorphism on platelet glycoprotein IIIa gene recognized by endonuclease Msp I: implications for Pl(A) typing by allele specific restriction analysis. Transfusion 1994;34:592-595.
Santoso S, Kalb R, Walka M, Kiefel V, Mueller-Eckhardt C, Newman PJ: The human platelet alloantigens Br(a) and Br(b) are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha2). J Clin Invest 1993;92:2427-2432.
Kroll H, Kiefel V, Giers G, Bald R, Hoch J, Hanfland P, Hansmann M, Mueller-Eckhardt C: Maternal intravenous immunoglobulin treatment does not prevent intracranial haemorrhage in fetal alloimmune thrombocytopenia. Transfus Med 1994;4:293-296.
Kalb R, Santoso S, Unkelbach K, Kiefel V, Mueller-Eckhardt C: Localization of the Br polymorphism on a 144 bp exon of the GPIa gene and its application for platelet DNA typing. Thromb Haemost 1994;71:651-654.
Greinacher A, Liebenhoff U, Kiefel V, Presek P, Mueller-Eckhardt C: Heparin-associated thrombocytopenia: the effects of various intravenous IgG preparations on antibody mediated platelet activation - a possible new indication for high dose i.v. IgG. Thromb Haemost 1994;71:641-645.
Kiefel V, Mueller-Eckhardt C: Report on the fifth International Society of Blood Transfusion Platelet Serology Workshop. Transfusion 1993;33:65-69.
Greinacher A, Zellner A, Brangenberg R, Kiefel V, Mueller-Eckhardt C: Das Bernard-Soulier-Syndrom. Eine wichtige Differentialdiagnose bei chronischer Thrombozytopenie mit Blutungskomplikationen. Monatsschr Kinderkeilkd 1993;141:483-486.
Santoso S, Santoso S, Kiefel V, Masri R, Mueller-Eckhardt C: Frequency of platelet-specific antigens among Indonesians. Transfusion 1993;33:739-741.
Meyer T, Herrmann C, Wiegand V, Mathias B, Kiefel V, Mueller-Eckhardt C: Immune thrombocytopenia associated with hemorrhagic diathesis due to ibuprofen administration. Clin Investig 1993;71:413-415.
Kiefel V, Kroll H, Bonnert J, Unkelbach K, Katzmann B, Nebenführer Z, Santoso S, Mueller-Eckhardt C: Platelet alloantigen frequencies in Caucasians: a serological study. Transfus Med 1993;3:237-242.
Greinacher A, Bux J, Kiefel V, White JG, Mueller-Eckhardt C: May-Hegglin anomaly: a rare cause of thrombocytopenia. Eur J Pediatr 1992;151:668-671.
Bux J, Kober B, Kiefel V, Mueller-Eckhardt C: Analysis of granulocyte-reactive antibodies using an immunoassay based upon monoclonal-antibody-specific immobilization of granulocyte antigens. Transfus Med 1993;3:157-162.
Santoso S, Kalb R, Kiefel V, Mueller-Eckhardt C: The presence of messenger RNA for HLA class I in human platelets and its capability for protein biosynthesis. Br J Haematol 1993;84:451-456.
Morel-Kopp MC, Blanchard B, Kiefel V, Joly C, Mueller-Eckhardt C, Kaplan C: Anti-HPA-4b (anti-Yuk(a)) neonatal alloimmune thrombocytopenia: first report in a Caucasian family. Transfus Med 1992;2:273-276.
Kuijpers RWAM, von dem Borne AEGK, Kiefel V, Mueller-Eckhardt C, Waters AH, Zupanska B, Barz D, Taaning E, Termijtelen A, Ouwehand WH: Leucine(33)-Proline(33) substitution in human platelet glycoprotein IIIa determines HLA-DRw52a (Dw24) association of the immune response against HPA-1a (Zw(a)/Pl(A1)) and HPA-1b (Zw(b)/Pl(A2)). Hum Immunol 1992;34:253-256.
Greinacher A, Michels I, Schäfer M, Kiefel V, Mueller-Eckhardt C: Heparin-associated thrombocytopenia in a patient treated with polysulphated chondroitin sulphate: evidence for immunological crossreactivity between heparin and polysulphated glycosaminoglycan. Br J Haematol 1992;81:252-254.
Greinacher A, Michels I, Kiefel V, Mueller-Eckhardt C: A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb Haemost 1991;66:734-736.
Santoso S, Kiefel V, Volz H, Mueller-Eckhardt C: Quantitation of soluble HLA class I antigen in human albumin and immunoglobulin preparations for intravenous use by solid-phase immunoassay. Vox Sang 1992;62:29-33.
Kiefel V, Santoso S, Kaufmann E, Mueller-Eckhardt C: Autoantibodies against platelet glycoprotein Ib/IX: a frequent finding in autoimmune thrombocytopenic purpura. Br J Haematol 1991;79:256-262.
Kaplan C, Morel-Kopp MC, Kiefel V, Schlegel N, Chesnel N, Mueller-Eckhardt C: HPA-5b (Br(a)) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases. Br J Haematol 1991;78:425-429.
Kiefel V, Shechter Y, Atias D, Kroll H, Santoso S, Mueller-Eckhardt C: Neonatal alloimmune thrombocytopenia due to anti-Br(b) (HPA-5a). Report of three cases in two families. Vox Sang 1991;60:244-245.
Giltay JC, Brinkman HJM, Vlekke A, Kiefel V, van Mourik JA, von dem Borne AEGK: The platelet glycoprotein Ia-IIa-associated Br-alloantigen system is expressed by cultured endothelial cells. Br J Haematol 1990;75:557-560.
Kroll H, Kiefel V, Santoso S, Mueller-Eckhardt C: Sr(a), a private platelet antigen on glycoprotein IIIa associated with neonatal alloimmune thrombocytopenia. Blood 1990;76:2296-2302.
Mueller-Eckhardt G, Kiefel V, Tlusty A, Scholten J, Schmidt A, Mueller-Eckhardt C: Incidence and specificity of HLA-DP antibodies in pregnancy sera. Hum Immunol 1990;29:166-174.
Santoso S, Kiefel V, Mueller-Eckhardt C: Blood group A and B determinants are expressed on platelet glycoproteins IIa, IIIa, and Ib. Thromb Haemost 1991;65:196-201.
Hammes HP, Kiefel V, Laube H, Federlin K: Impaired agglutination of IgM resulting from non-enzymatic glycation in diabetes mellitus. Diabetes Res Clin Pract 1990;9:37-42.
Mueller-Eckhardt C, Kiefel V, Kroll H, Mueller-Eckhardt G: HLA-DRw6, a new immune response marker for immunization against the platelet alloantigen Br(a). Vox Sang 1989;57:90-91.
Mueller-Eckhardt G, Pawelec G, Haas R, Otto C, Kiefel V, Odum N, Mueller-Eckhardt C: HLA-DP antigens in patients with chronic autoimmune thrombocytopenia (AITP). Tissue Antigens 1989;34:121-126.
Santoso S, Kiefel V, Mueller-Eckhardt C: Human platelet alloantigens Br(a)/Br(b) are expressed on the very late activation antigen 2 (VLA-2) of T-lymphocytes. Hum Immunol 1989;25:237-246.
Panzer S, Kiefel V, Bartram CR, Haas OA, Hinterberger W, Mueller-Eckhardt C, Lechner K: Immune thrombocytopenia more than a year after allogeneic marrow transplantation due to antibodies against donor platelets with anti-Pl(A1) specificity: evidence for a host-derived immune reaction. Br J Haematol 1989;71:259-264.
Neppert J, Mueller-Eckhardt G, Neumayer H, Malchus R, Kiefel V, Gerhard I, Kuhn U, Westphal E, Harpprecht J: Pregnancy-maintaining antibodies: workshop report (Giessen, 1988). J Reprod Immunol 1989;15:159-167.
Mueller-Eckhardt G, Kiefel V, Schmidt A, Tlusty A, Santoso S, Mueller-Eckhardt C: Discrimination of antibodies against antigens of different MHC loci in human sera by monoclonal antibody-specific immobilization of leukocyte antigens. Hum Immunol 1989;25:125-134.
Inostroza J, Kiefel V, Mueller-Eckhardt C: Frequency of platelet-specific antigens Pl(A1), Bak(a), Yuk(a), Yuk(b), and Br(a) in South American (Mapuches) indians. Transfusion 1988;28:586-587.
Salama A, Schütz B, Kiefel V, Breithaupt H, Mueller-Eckhardt C: Immune-mediated agranulocytosis related to drugs and their metabolites: mode of sensitization and heterogeneity of antibodies. Br J Haematol 1989;72:127-132.
Mueller-Eckhardt C, Kiefel V, Grubert A, Kroll H, Weisheit M, Schmidt S, Mueller-Eckhardt G, Santoso S: 348 cases of suspected neonatal alloimmune thrombocytopenia. Lancet 1989;i:363-366.
Mueller-Eckhardt C, Kiefel V, Grubert A: High-dose IgG treatment for neonatal alloimmune thrombocytopenia. Blut 1989;59:145-146.
Mueller-Eckhardt C, Kiefel V: High-dose IgG for post-transfusion purpura - revisited. Blut 1988;57:163-167.
Kiefel V, Salama A, Mueller-Eckhardt C: In vitro fixation of C3d and C5b-9 on platelets by human platelet reactive antibodies. Blut 1989;58:33-37.
Kiefel V, Santoso S, Glöckner WM, Katzmann B, Mayr WR, Mueller-Eckhardt C: Posttransfusion purpura associated with an anti-Bak(b). Vox Sang 1989;56:93-97.
Langenscheidt F, Kiefel V, Santoso S, Nau A, Mueller-Eckhardt C: Quantitation of platelet antigens after chloroquine treatment. Eur J Haematol 1989;42:186-192.
Benda H, Panzer S, Kiefel V, Mannhalter C, Hinterberger W, Lechner K, Mueller-Eckhardt C: Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation. Blut 1989;58:151-153.
Santoso S, Kiefel V, Mueller-Eckhardt C: Immunochemical characterization of the new platelet alloantigen system Br(a)/Br(b). Br J Haematol 1989;72:191-198.
Kiefel V, Santoso S, Mueller-Eckhardt C: The Br(a)/Br(b) alloantigen system on human platelets. Blood 1989;73:2219-2223.
Langenscheidt F, Kiefel V, Santoso S, Mueller-Eckhardt C: Platelet transfusion refractoriness associated with two rare platelet-specific alloantibodies (anti-Bak(a) and anti-Pl(A2)) and multiple HLA-antibodies. Transfusion 1988;28:597-600.
Salama A, Hugo F, Heinrich D, Höge R, Müller R, Kiefel V, Mueller-Eckhardt C: Deposition of terminal C5b-9 complement complexes on erythrocytes and leukocytes during cardiopulmonary bypass. N Engl J Med 1988;318:408-414.
Santoso S, Kiefel V, Mueller-Eckhardt C: Redistribution of platelet glycoproteins induced by allo- and autoantibodies. Thromb Haemost 1987;58:866-871.
Kiefel V, Santoso S, Katzmann B, Mueller-Eckhardt C: A new platelet-specific alloantigen Br(a). Report of 4 cases with neonatal alloimmune thrombocytopenia. Vox Sang 1988;54:101-106.
Kiefel V, Santoso S, Weisheit M, Mueller-Eckhardt C: Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet reactive antibodies. Blood 1987;70:1722-1726.
Kiefel V, Jäger S, Mueller-Eckhardt C: Competitive enzyme-linked immunoassay for the quantitation of platelet-associated immunoglobulins (IgG, IgM, IgA) and complement (C3c, C3d). Vox Sang 1987;53:151-156.
Santoso S, Shibata Y, Kiefel V, Mueller-Eckhardt C: Identification of the Yuk(b) allo-antigen on platelet glycoprotein IIIa. Vox Sang 1987;53:48-51.
Panzer S, Kiefel V, Mayr WR, Fielder AHL, Lachmann D, Mueller-Eckhardt C: Pedigree of the major histocompatibility complex in a family with a neonatal alloimmune thrombocytopenia. Biol Neonate 1987;51:194-197.
Mueller-Eckhardt C, Allolio B, Salama A, Kiefel V, Deuss U: Nomifensine-dependent immune hemolytic anemia and posttransfusion purpura in the same patient. Transfusion 1987;27:250-252.
Kiefel V, Santoso S, Schmidt S, Salama A, Mueller-Eckhardt C: Metabolite-specific (IgG) and drug-specific antibodies (IgG, IgM) in two cases of trimethoprim-sulfamethoxazole-induced immune thrombocytopenia. Transfusion 1987;27:262-265.
Santoso S, Mueller-Eckhardt G, Santoso S, Kiefel V, Mueller-Eckhardt C: HLA antigen on platelet membranes. In vitro and in vivo studies. Vox Sang 1986;51:327-333.
Salama A, Kiefel V, Mueller-Eckhardt C: Effect of IgG anti-Rh(o) (D) in adult patients with chronic autoimmune thrombocytopenia. Am J Hematol 1986;22:241-250.
Mueller-Eckhardt C, Kiefel V, Mueller-Eckhardt G, Bambauer R, Baur J, Behringhoff B, Deuss U, Heinrich D, Klein HO, Lechner K, Maas D, Panzer S, Sprenger R, Stählin H, Vahrson H: Posttransfusion purpura. A survey of 13 cases. Klin Wochenschr 1986;64:1198-1203.
Kiefel V, Spaeth P, Mueller-Eckhardt C: Immune thrombocytopenic purpura: autoimmune or immune complex disease? Br J Haematol 1986;64:57-68.
Becker T, Küenzlen E, Salama A, Mertens R, Kiefel V, Weiß H, Lampert F, Gaedicke G, Mueller-Eckhardt C: Treatment of childhood idiopathic thrombocytopenic purpura with Rhesus antibodies (anti-D). Eur J Pediatr 1986;145:166-169.
Kiefel V, Becker T, Mueller-Eckhardt G, Grebe S, Mueller-Eckhardt C: Platelet survival determined with (51)Cr versus (111)In. Klin Wochenschr 1985;63:84-89.
Mueller-Eckhardt C, Salama A, Mahn I, Kiefel V, Neuzner J, Graubner M: Lack of efficacy of high-dose intravenous immunoglobulin in autoimmune haemolytic anaemia: a clue to its mechanism. Scand J Haematol 1985;34:394-400.
Becker T, Panzer S, Maas D, Kiefel V, Sprenger R, Kirschbaum M, Mueller-Eckhardt C: High-dose intravenous immunoglobulin for post-transfusion purpura. Br J Haematol 1985;61:149-155.
Salama A, Kiefel V, Amberg R, Mueller-Eckhardt C: Treatment of autoimmune thrombocytopenic purpura with rhesus antibodies (anti-Rh(o)(D)). Blut 1984;49:29-35.
Panzer S, Mueller-Eckhardt G, Salama A, Strauss BE, Kiefel V, Mueller-Eckhardt C: The clinical significance of HLA antigens on red cells. Survival studies in HLA-sensitizes individuals. Transfusion 1984;24:486-489.
Salama A, Mueller-Eckhardt C, Kiefel V: Effect of intravenous immunoglobulin in immune thrombocytopenia. Competitive inhibition of reticuloendothelial system function by sequestration of autologous red blood cells? Lancet 1983;ii:193-196.
Mueller-Eckhardt C, Küenzlen E, Kiefel V, Vahrson H, Graubner M: Cyclophosphamide-induced immune thrombocytopenia in a patient with ovarian carcinoma successfully treated with intravenous gamma globulin. Blut 1983;46:165-169.
Zuletzt aktualisiert am 8. August 2001